Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2014 Nov 1.

Published in final edited form as: Bioorg Med Chem Lett. 2013 Sep 5;23(21):10.1016/j.bmcl.2013.08.103. doi: 10.1016/j.bmcl.2013.08.103

Table 1.

Favored positioning of Ar² substituent(s)


Compound	R	LASV EC₅₀ (nM)
3a	H	47
3b	2-Cl	320
3c	4-Cl	20
3d	3-Br	56
3e	4-Br	470
3f	3-NO₂	250
3g	4-NO₂	62
3h	2-OH	570
3i	3-OH	94
3j	4-OH	2.3
3k	3-OMe	42
3l	4-OMe	4.0
3m	3-Me	58
3n	4-Me	9.0
3o	2,3-diMe	800
3p	2,4-diMe	170
3q	3,4-diMe	3.9
3r	3,4-diCl	72
3s	3,4-diOMe	450
3t	4-cyclohexyl	24
3u	4-phenyl	1.3
3v	4-NHAc	2.6
3w		2.1
3x		6300
3y		0.95
3z		0.34