Table 2.

Effect of bulky Ar¹ substituent

Compound	R	R′	LASV EC50 (nM)
3a	H	H	47
4a	t-Bu	H	15
3c	H	4-Cl	20
4b	t-Bu	4-Cl	6.6
4c	H	4-F	52
4d	t-Bu	4-F	16
4e	H		9100
4f	t-Bu		770