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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Amino Acids. 2011 Jul 9;42(6):10.1007/s00726-011-0970-7. doi: 10.1007/s00726-011-0970-7

Table 2. Inhibition constants of Streptococcus pyogenes P5C reductase activity for two of the most active phenyl derivatives of compound 01.

Compound 08 (μM) Compound 19 (μM)
KI against l-P5Ca(NADH) 0.67 ± 0.04 0.98 ± 0.07
KI against l-P5Ca(NADPH) 0.81 ± 0.01 ND
KI against NADHb 0.11 ± 0.01 0.37 ± 0.00
KI against NADPHb 0.68 ± 0.06 ND

ND not determined

a

Uncompetitive inhibition, KI value estimated from Lineweaver–Burk plots

b

Noncompetitive inhibition, KI value estimated from Dixon plots