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. Author manuscript; available in PMC: 2013 Nov 21.
Published in final edited form as: Fertil Steril. 2012 Jul 20;98(3):10.1016/j.fertnstert.2012.06.029. doi: 10.1016/j.fertnstert.2012.06.029

Table 1.

Candidate factors implicated in the pathophysiology of endometriosis

Gene Function Reference(s)
17βHSD-2 Hydroxysteroid dehydrogenase Zeitoun et al 1998 (47)
BCL-2 Anti-apoptosis Jones et al 1998 (31)
CYP19 Aromatase enzyme Noble et al 1996 (101)
HOXA10 Transcription factor Taylor et al 1999 (102)
IL-6 Cytokine Harada et al 1997 (81)
KRAS Oncogene Dinulescu et al 2005 (30)
MMP 3,7 Matrix metalloproteinases Bruner-Tran et al 2002 (65)
NF-KB Transcription factor Gonzalez-Ramos et al 2010 (103)
PGE2 Prostaglandin Badawy et al 1984 (104)
PTEN Tumor suppressor gene Dinulescu et al 2005 (30)
TGF-B Cytokine Oosterlynck et al 1994 (61)
TNF-α Cytokine Eisermann et al 1988 (80)