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. 2013 Nov 21;9(11):e1003947. doi: 10.1371/journal.pgen.1003947

Figure 7. DUX4-bound regions are similarly activated in FSHD patient myotubes and in DUX4-transduced myoblasts.

Figure 7

(A) DUX4-bound regions show correlated activation levels in FSHD patient myotubes and in our DUX4-transduced myoblast experimental system. We show log2-activation levels in each system, counting RNA-seq reads within an arbitrary 1 kb of DUX4-bound regions as for Figure 3A. “+” symbols show bound repetitive elements and dot symbols are unique regions. Green symbols show regions that reach statistical significance in only the DUX4-transduced myoblasts, blue symbols are significant in only the FSHD myotubes, and red symbols are significant in both comparisons. The dotted line is a regression line (slope 0.265). (B) Internal regions of ERV and MaLR repeats show correlated activation levels in FSHD patient myotubes and in our DUX4-transduced myoblast experimental system. Colors as in panel A. The dotted line is a regression line (slope 0.270).