Figure 5. Information and conditional profiles of three pairwise comparisons of human chromosomes 22.

Parameters are similar to those of Fig. 1, except for the smoothing window, which has a value of 100,001-context models trained over the GRCh37 human genome assembly. Peaks in these profiles highlight regions of sequence divergence in the KOREF, HuRef and Celera chromosomes, with respect to the GRCh37 one. As an example of the additional information conveyed by these conditional profiles, we highlight the peak in the Celera assembly around base 43 Mb. Whereas slightly perceivable in the non-conditional profiles, the divergence of the two assemblies (GRCh37 and Celera) at this particular location is much more evident in the conditional profile.