Table 2. Univariate (adjusted for sex) and multivariable hazard ratios (HR) for five-year cardiovascular morbidity and cardiovascular mortality^a, depending on traditional and new risk markers, in participants with a history of cardiovascular disease (N=282).

		HR (95% confidence interval) for cardiovascular morbidity and mortalitya
		Univariate	Multivariable
			All traditional	All trad.	All trad.	All trad.	All trad.	All trad.	All trad.
				+ major CVD	+ MDRD (SD)	+ CRP (SD)	+ HCYb (SD)	+ NT-proBNP (SD)	+all new
Traditional risk markers
	Men	1.4 (0.96-2.0)	1.3 (0.85-2.0)	1.2 (0.79-1.9)	1.4 (0.93-2.2)	1.3 (0.86-2.0)	1.3 (0.85-2.0)	1.3 (0.83-1.9)	1.2 (0.74-1.8)
	RR (∆10 mmHg)	0.95 (0.86-1.1)	0.93 (0.84-1.0)	0.93 (0.84-1.0)	0.93 (0.84-1.0)	0.92 (0.83-1.0)	0.95 (0.85-1.1)	0.96 (0.86-1.1)	0.96 (0.87-1.1)
	Total chol (SD)	1.1 (0.91-1.4)	1.1 (0.92-1.4)	1.1 (0.91-1.4)	1.1 (0.91-1.4)	1.2 (0.94-1.4)	1.1 (0.91-1.4)	1.2 (0.99-1.5)	1.2 (0.98-1.5)
	HDL chol (SD)	1.0 (0.83-1.3)	1.0 (0.82-1.2)	1.0 (0.3-1.3)	1.1 (0.87-1.3)	1.1 (0.87-1.3)	1.1 (0.88-1.3)	1.1 (0.86-1.3)	1.1 (0.92-1.4)
	DM	1.1 (0.66-1.8)	1.1 (0.70-1.9)	1.1 (0.68-1.9)	1.1 (0.67-1.8)	1.1 (0.67-1.8)	1.2 (0.70-1.9)	1.0 (0.62-1.7)	1.0 (0.62-1.7)
	Current smoking	1.9 (1.2-3.0)	1.9 (1.2-3.1)	1.9 (1.2-3.1)	2.0 (1.2-3.2)	2.0 (1.2-3.1)	1.8 (1.1-3.0)	1.8 (1.1-3.0)	1.8 (1.1-2.9)
Major CVD c		1.5 (1.03-2.3)		1.5 (1.001-2.2)					1.5 (1.01-2.3)
New risk markers
	MDRD (SD)	0.83 (0.68-1.01)			0.81 (0.65-3.7)				1.1 (0.85-1.3)
	CRP (SD)	1.3 (1.03-1.5)				1.3 (1.1-1.6)			1.2 (0.97-1.4)
	HCYb (SD)	1.4 (1.1-1.6)					1.3 (1.1-1.6)		1.2 (0.99-1.6)
	NT-proBNP (SD)	1.7 (1.4-2.1)						1.8 (1.4-2.2)	1.6 (1.3-2.1)

CRP, homocysteine and NT-proBNP are log transformed;^a including incident stroke, myocardial infarction or cardiovascular mortality;^b HCY: homocysteine;

^cincluding a history of myocardial infarction, stroke or arterial surgery