Table 3. C- statistic, categoryless net reclassification improvement (NRI), integrated discrimination improvement (IDI) and relative IDI (rIDI) of the different models for prediction of five-year cardiovascular morbidity and mortality ^a in participants with a history of cardiovascular disease (N=282), all compared to a model with traditional risk markers ^b .

	C-statistic	95% CI	∆ C-statistic c	p-value∆c	categoryless NRI c (%)	p-valueNRI c	IDI c	p-valueIDI c	rIDI d
Traditional risk markers	0.59	0.52-0.66
+ major CVD	0.60	0.53-0.67	0.01	0.59	27.2	0.03	0.012	0.30	0.46
+ MDRD	0.59	0.52 -0.66	0.00	0.74	6.2	0.61	0.0025	0.81	0.095
+ CRP	0.60	0.54 -0.67	0.01	0.65	16.8	0.17	0.008	0.47	0.31
+ Homocysteine	0.62	0.55 -0.69	0.03	0.27	24.7	0.04	0.019	0.13	0.72
+ NT-proBNP	0.67	0.61 -0.74	0.08	0.023	39.0	0.001	0.067	<0.001	2.55
+ all five	0.69	0.62- 0.75	0.10	0.0067	50.8	<0.001	0.089	<0.001	3.39

CRP, homocysteine and NT-proBNP are log transformed;

^aincluding incident stroke, myocardial infarction or cardiovascular mortality;

^bincluding sex, systolic blood pressure, total cholesterol, HDL cholesterol, diabetes, current smoking;

^cfor comparison against traditional risk markers;

^dfor comparison with the discrimination of the model with the traditional risk markers (0.026 in this study)