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Saponin 1 treatment resulted in a time-dependent decrease in the expressions of NF-κB p65, survivin and XIAP in glioblastoma cell lines. The ratio of Bcl-2/Bax rapidly diminished and the activation of caspase-9 and caspase-3 was observed. Endogenous expression of these proteins was not changed in primary cultured astrocytes exposed to saponin-1-treatment.
