Table 1.
Model Data Inputs
| Variable | Distribution Type |
Mean,a Median,b or Modec |
Standard Deviation or Range |
Reference |
|---|---|---|---|---|
| Patient characteristics | ||||
| Age of pregnant women, y | — | 27.1b | — | 19 |
| QALY value: inpatient treatment of wound infection | — | 0.60 | — | 31 |
| QALY value: outpatient treatment of wound infection | — | 0.70 | — | 31 |
| Costs, $ | ||||
| Laboratory | ||||
| Agar screening/wound culture | — | 12.34a | 0.95 | 29 |
| PCR screening/wound culture | — | 50.27a | 5.53 | 29 |
| Pharmaceuticals | ||||
| Cephalexin (per day) | γ | 7.47a | 5.71 | 28 |
| Chlorhexidine (full course) | γ | 6.44a | 2.88 | 28 |
| Mupirocin (full course) | γ | 8.07a | 1.38 | 28 |
| Sulfamethoxazole-trimethoprim (per day) | γ | 3.29a | 1.27 | 28 |
| Unasyn (per day) | γ | 65.25a | 14.80 | 28 |
| Vancomycin (per day) | γ | 31.49a | 16.84 | 28 |
| Hospitalization | ||||
| Maternal hospitalization for wound infection | γ | 6110.53a | 394.47 | 26,27 |
| Procedures and supplies | ||||
| Home health supplies (per week) | γ | 34.78a | 6.96 | Assumptiond |
| Home health visitation (per week) | γ | 469.75a | 93.91 | Assumptiond |
| Open wound incision in outpatient setting | γ | 50.41a | 4.55 | 30 |
| Open wound incision in OR | γ | 735.18a | 45.54 | 30 |
| Open wound incision on ward | γ | 74.89a | 7.20 | 30 |
| Duration, days | ||||
| Antibiotic treatment for MRSA | — | 7–14 | — | 25 |
| Antibiotic treatment for MSSA | — | 7 | — | 25 |
| Empiric antibiotic treatment | Δ | 1.5 c | 1.0–2.0 | Assumptiond |
| Home health treatment | Δ | 28c | 14–42 | Assumptiond |
| Maternal hospitalization for wound infection | γ | 3.8a | 0.1 | 26,27 |
| Probability, % | ||||
| Conditions and procedures | ||||
| Wound infection if S aureus colonized | Δ | 9 | 4–20 | 2,15,21–24 |
| Wound infection if not S aureus colonized | Δ | 2.25 | 0.8–6.67 | 2,15,21–24 |
| Hospitalization (given wound infection) | Δ | 2.0c | 1.5–2.5 | 32, Assumptiond |
| Inpatient wound-opening procedure (given hospitalization) | Δ | 95c | 91–99 | Assumptiond |
| Wound opening in OR | Δ | 15c | 0–36 | Assumptiond |
| Wound opening on ward | Δ | 85c | 64–1 | Assumptiond |
| Outpatient wound-opening procedure | Δ | 20 | 5–40 | Assumptiond |
| Home health after wound opening | — | 75 | — | Assumptiond |
| Home health after outpatient wound opening | — | 25 | — | Assumptiond |
| Laboratory | ||||
| Agar culture sensitivity | Δ | 90 | 95.5–100 | 33–36 |
| Agar culture specificity | Δ | 95 | 97.5–100 | 33–36 |
| PCR sensitivity | Δ | 97 | 98.125–100 | 33–36 |
| PCR specificity | Δ | 95.5 | 98.34–100 | 33–36 |
| Sensitivity analyses | Values | Source | ||
| Probability of colonization | 1%–50% (by increments of 5%) | Assumption | ||
| Probability of successful decolonization | 25%, 50%, 75%, 90% | Assumption | ||
| Laboratory technique (screening/wound isolate) | Agar-agar, PCR-agar, PCR-PCR | Assumption | ||
MRSA indicates methicillin-resistant Staphylococcus aureus; MSSA, methicillin-susceptible Staphylococcus aureus; OR, operating room; PCR, polymerase chain reaction; QALY, quality-adjusted life-year.
a
Mean value.
b
Median value.
c
Mode value.
d
Assumption based on experience at Magee-Womens Hospital.