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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Anesth Analg. 2013 Mar 14;116(6):10.1213/ANE.0b013e31828b3637. doi: 10.1213/ANE.0b013e31828b3637

Figure 1.

Figure 1

A, Chemical structures of etomidate, carboetomidate, and azi-etomidate. B, Inhibition of cortisol synthesis by azi-etomidate and etomidate. At all concentrations studied, azi-etomidate and etomidate reduced cortisol concentrations in wells containing H295R cells 24 hours after simulation with forskolin. Control (no drug) cortisol concentrations were 1.86 ± 0.10 ng/mL. ***P < 0.001 versus control value; 1-way analysis of variance followed by a Dunnett multiple comparison post-test. Each column shows the mean ± SD from 4 to 8 wells.