Table 1.
Functional categories of selected genes that significantly differ between alcoholics and controls (FDR ≤ 0.20)
| A. Inflammatory / immune
response GO (0006954 & 0006955) | ||||
|---|---|---|---|---|
| Gene symbol | Gene title | Fold | p value | FDR |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
−1.55 | 1.1E-02 | 0.21 |
| TAC1 | tachykinin, precursor 1 | −1.53 | 2.9E-02 | 0.27 |
| TNFSF10 | tumor necrosis factor
(ligand) superfamily, member 10 |
−1.37 | 1.5E-02 | 0.23 |
| LIPA | lipase A, lysosomal acid,
cholesterol esterase |
−1.34 | 1.4E-03 | 0.13 |
| HDAC9 | histone deacetylase 9 | −1.31 | 7.8E-03 | 0.19 |
| PXK | PX domain containing
serine/threonine kinase |
−1.31 | 5.8E-03 | 0.18 |
| IKBKAP | inhibitor of kappa light polypeptide
gene enhancer in B-cells, kinase complex-associated protein |
−1.23 | 3.8E-04 | 0.08 |
| SEMA4D | sema domain, immunoglobulin
domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, |
−1.22 | 1.2E-02 | 0.21 |
| KLRG1 | killer cell lectin-like receptor
subfamily G, member 1 |
−1.21 | 5.6E-04 | 0.10 |
| BLNK | B-cell linker | −1.20 | 3.2E-02 | 0.28 |
| OAS1 | 2’,5’-oligoadenylate
synthetase 1, 40/46kDa |
−1.20 | 2.6E-03 | 0.15 |
| PRKRA | protein kinase,
interferon-inducible double stranded RNA dependent activator |
−1.20 | 2.7E-02 | 0.27 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) |
−1.18 | 3.6E-02 | 0.29 |
| IGKC | immunoglobulin kappa constant | −1.13 | 1.6E-02 | 0.23 |
| TRAF6 | TNF receptor-associated factor 6 | −1.12 | 4.1E-03 | 0.16 |
| ITCH | itchy E3 ubiquitin protein
ligase homolog (mouse) |
−1.11 | 2.7E-02 | 0.27 |
| ADORA1 | adenosine A1 receptor | −1.11 | 3.4E-03 | 0.16 |
| AKT1 | v-akt murine thymoma viral
oncogene homolog 1 |
1.08 | 7.0E-03 | 0.19 |
| GTPBP1 | GTP binding protein 1 | 1.10 | 3.1E-03 | 0.15 |
| KIR2DL3 | killer cell immunoglobulin-like
receptor, two domains, long cytoplasmic tail, 3 |
1.10 | 2.7E-02 | 0.27 |
| FCGRT | Fc fragment of IgG,
receptor, transporter, alpha |
1.12 | 2.7E-02 | 0.27 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta |
1.13 | 3.7E-02 | 0.29 |
| LTB4R | leukotriene B4 receptor | 1.13 | 6.5E-03 | 0.18 |
| FTH1 | ferritin, heavy polypeptide 1 | 1.13 | 3.0E-02 | 0.28 |
| SMAD1 | SMAD family member 1 | 1.14 | 1.5E-02 | 0.23 |
| MR1 | major histocompatibility complex,
class I-related |
1.15 | 3.2E-02 | 0.28 |
| PROK2 | prokineticin 2 | 1.15 | 3.5E-02 | 0.29 |
| ULBP2 | UL16 binding protein 2 | 1.18 | 2.8E-02 | 0.27 |
| S1PR3 | sphingosine-1-phosphate receptor 3 | 1.20 | 1.4E-02 | 0.22 |
| TGFBR3 | transforming growth factor,
beta receptor III |
1.25 | 1.2E-02 | 0.21 |
| TNFRSF1A | tumor necrosis factor
receptor superfamily, member 1A |
1.25 | 2.6E-03 | 0.15 |
| KIR2DL3 | killer cell immunoglobulin-like
receptor, two domains, long cytoplasmic tail, 3 |
1.27 | 3.1E-02 | 0.28 |
| C1R | complement component 1,
r subcomponent |
1.27 | 7.8E-03 | 0.19 |
| PNP | purine nucleoside phosphorylase | 1.27 | 2.9E-03 | 0.15 |
| TARP | TCR gamma alternate reading
frame protein |
1.39 | 3.0E-04 | 0.08 |
| IFITM2 | interferon induced
transmembrane protein 2 (1–8D) |
1.46 | 1.7E-03 | 0.14 |
| SLC11A1 | solute carrier family 11
(proton-coupled divalent metal ion transporters), member 1 |
1.51 | 2.1E-03 | 0.14 |
| IL4R | interleukin 4 receptor | 1.57 | 2.1E-04 | 0.08 |
| IFITM3 | interferon induced
transmembrane protein 3 (1-8U) |
1.60 | 6.2E-05 | 0.05 |
| IL1R1 | interleukin 1 receptor, type I | 1.71 | 1.7E-05 | 0.03 |
| CD163 | CD163 molecule | 1.80 | 3.7E-03 | 0.16 |
| S100A8 | S100 calcium binding protein A8 | 1.85 | 7.8E-03 | 0.19 |
| IL1RL1 | interleukin 1 receptor-like 1 | 1.87 | 7.9E-04 | 0.11 |
| SERPINA3 | serpin peptidase inhibitor, clade
A (alpha-1 antiproteinase, antitrypsin), member 3 |
2.28 | 4.0E-03 | 0.16 |
| B. Hypoxia GO (0001666) | ||||
| Gene symbol | Gene title | Fold | p value | FDR |
| ITGA2 | integrin, alpha 2 (CD49B, alpha
2 subunit of VLA-2 receptor) |
−1.40 | 1.5E-02 | 0.23 |
| PYGM | phosphorylase, glycogen, muscle | −1.29 | 2.8E-02 | 0.27 |
| VLDLR | very low density lipoprotein receptor | −1.28 | 3.7E-03 | 0.16 |
| PRKCQ | protein kinase C, theta | −1.21 | 2.8E-02 | 0.27 |
| HSP90B1 | heat shock protein 90kDa beta
(Grp94), member 1 |
−1.17 | 1.5E-02 | 0.23 |
| ADAM17 | ADAM metallopeptidase domain 17 | −1.14 | 3.0E-02 | 0.28 |
| BIRC2 | baculoviral IAP repeat-containing 2 | −1.13 | 1.7E-02 | 0.24 |
| EGLN2 | egl nine homolog 2 (C. elegans) | 1.10 | 8.0E-03 | 0.19 |
| PLD2 | phospholipase D2 | 1.11 | 2.9E-02 | 0.28 |
| ECE1 | endothelin converting enzyme 1 | 1.14 | 3.7E-02 | 0.29 |
| HIF1A | hypoxia inducible factor 1,
alpha subunit (basic helix-loop-helix transcription factor) |
1.15 | 2.0E-02 | 0.25 |
| SOD2 | superoxide dismutase 2, mitochondrial | 1.16 | 1.7E-02 | 0.24 |
| SDC2 | syndecan 2 | 1.18 | 2.5E-02 | 0.27 |
| ADM | adrenomedullin | 1.25 | 2.2E-02 | 0.26 |
| SOCS3 | suppressor of cytokine signaling 3 | 1.31 | 7.6E-03 | 0.19 |
| TGFB3 | transforming growth factor, beta 3 | 1.32 | 3.7E-02 | 0.29 |
| DDIT4 | DNA-damage-inducible transcript 4 | 1.39 | 7.9E-03 | 0.19 |
| HIF3A | hypoxia inducible factor 3,
alpha subunit |
1.40 | 1.5E-03 | 0.13 |
| PDLIM1 | PDZ and LIM domain 1 | 1.42 | 1.1E-02 | 0.21 |
| ANGPTL4 | angiopoietin-like 4 | 1.57 | 8.6E-05 | 0.06 |
| EDN1 | endothelin 1 | 1.65 | 3.3E-04 | 0.08 |
| C. HPA Axis | ||||
| Gene symbol | Gene title | Fold | p value | FDR |
| HSPA1A | heat shock 70kDa protein 1A | −1.47 | 7.7E-03 | 1.9E-01 |
| HSP90AA1 | heat shock protein 90kDa
alpha (cytosolic), class A member 1 |
−1.37 | 3.7E-04 | 8.5E-02 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | −1.29 | 1.9E-03 | 1.4E-01 |
| NR3C1 | nuclear receptor subfamily 3, group
C, member 1 (glucocorticoid receptor) |
−1.29 | 1.8E-05 | 2.7E-02 |
| HSPA8 | heat shock 70kDa protein 8 | −1.26 | 7.7E-03 | 1.9E-01 |
| FKBP4 | FK506 binding protein 4, 59kDa | −1.16 | 3.4E-03 | 1.6E-01 |
| FKBP5 | FK506 binding protein 5 | 2.21 | 4.6E-06 | 2.1E-02 |
| D. Myelination | ||||
| Gene symbol | Gene title | Fold | p value | FDR |
| UGT8 | UDP glycosyltransferase 8 | −1.73 | 1.4E-04 | 0.07 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
−1.55 | 1.1E-02 | 0.21 |
| KLK6 | kallikrein-related peptidase 6 | −1.46 | 3.0E-03 | 0.15 |
| MOG | myelin oligodendrocyte glycoprotein | −1.46 | 3.6E-03 | 0.16 |
| TF | transferrin | −1.44 | 6.0E-03 | 0.18 |
| ASPA | aspartoacylase | −1.28 | 6.6E-02 | 0.33 |
| PLP1 | proteolipid protein 1 | −1.26 | 1.6E-03 | 0.14 |
| OMG | oligodendrocyte myelin glycoprotein | −1.25 | 3.9E-03 | 0.16 |
| PLLP | plasmolipin | −1.23 | 1.9E-02 | 0.25 |
| MAG | myelin associated glycoprotein | −1.23 | 8.1E-02 | 0.35 |
| CNP | 2’,3’-cyclic nucleotide
3’ phosphodiesterase |
−1.20 | 4.2E-02 | 0.30 |
| ERBB3 | v-erb-b2 erythroblastic leukemia
viral oncogene homolog 3 (avian) |
−1.20 | 4.3E-02 | 0.31 |
| PMP2 | peripheral myelin protein 2 | −1.18 | 5.8E-02 | 0.33 |
| MYEF2 | myelin expression factor 2 | −1.09 | 3.6E-02 | 0.29 |
| MYT1 | myelin transcription factor 1 | 1.16 | 2.4E-02 | 0.26 |
| MPZL2 | myelin protein zero-like 2 | 1.84 | 1.5E-03 | 0.14 |
| E. Metallothioneins | ||||
| Gene symbol | Gene title | Fold | p value | FDR |
| MT1X | metallothionein 1X | 1.98 | 1.8E-05 | 0.03 |
| MT1M | metallothionein 1M | 1.50 | 1.1E-03 | 0.13 |
| MT1A | metallothionein 1A | 1.48 | 2.6E-04 | 0.08 |
| MT2A | metallothionein 2A | 1.47 | 1.1E-03 | 0.13 |
| MT1G | metallothionein 1G | 1.38 | 2.1E-02 | 0.25 |
| MT1L | metallothionein 1L (gene/pseudogene) | 1.37 | 2.0E-03 | 0.14 |
| MT1JP | metallothionein 1J (pseudogene) | 1.26 | 1.6E-02 | 0.23 |
| MT1P3 | metallothionein 1 pseudogene 3 | 1.25 | 3.3E-03 | 0.16 |
| MT1DP | metallothionein 1D (pseudogene) | 1.24 | 7.1E-03 | 0.19 |
| MT1E | metallothionein 1E | 1.22 | 5.7E-02 | 0.33 |
| MT1B | metallothionein 1B | 1.21 | 1.1E-02 | 0.21 |
| MT1P2 | metallothionein 1 pseudogene 2 | 1.21 | 6.9E-03 | 0.19 |
| MT1F | metallothionein 1F | 1.19 | 1.1E-01 | 0.37 |
| MT3 | metallothionein 3 | 1.16 | 6.1E-02 | 0.33 |
| MT1H | metallothionein 1H | 1.15 | 6.4E-02 | 0.33 |
| MT1IP | metallothionein 1I (pseudogene) | 1.14 | 4.6E-02 | 0.31 |
| MT4 | metallothionein 4 | 1.13 | 7.4E-02 | 0.34 |