Table 4. Anthropometric measures, body composition, and blood pressure in the two groups at baseline and follow-up: analysis restricted to participants who completed the study on assigned treatment condition.

	Baseline		Week 26		Change from baseline			Week 52		Change from baseline
	FB (n=45)	MD (n=50)	FB (n=45)	MD (n=50)	FB (n=45)	MD (n=50)	P valuea	FB (n=45)	MD (n=50)	FB (n=45)	MD (n=50)	P valueb
Weight (kg)	113.1c	112.0	108.7	103.5	−4.4*	−8.5*	0.0001	110.4	106.7	−2.7*	−5.3*	0.0010
	[113.1]d	[112.8]	[108.7]	[104.3]	[−4.4† ]	[−8.5† ]	[0.0094]	[110.5]	[107.5]	[−2.7† ]	[−5.3† ]	[0.0569]
	(12.5)e	(17.4)	(13.7)	(17.0)	(7.4)	(8.3)		(13.3)	(17.1)	(6.7)	(7.2)
BMI (kg/m2)	41.5	40.4	39.9	37.4	−1.6*	−3.0*	0.0003	40.6	38.6	−0.9*	−1.8*	0.0024
	[41.4]	[40.6]	[39.8]	[37.6]	[−1.6† ]	[−3.0† ]	[0.0111]	[40.4]	[38.7]	[−0.9† ]	[−1.8† ]	[0.0661]
	(3.7)	(3.9)	(4.5)	(4.7)	(2.5)	(2.7)		(4.3)	(4.4)	(2.2)	(2.5)
Waist (cm)	111.8	107.0	107.4	100.7	−4.4*	−6.3*	0.0073	107.6	101.5	−4.2*	−5.4*	0.0114
	[111.9]	[107.2]	[107.4]	[100.9]	[−4.4† ]	[−6.3† ]	[0.0470]	[107.7]	[101.7]	[−4.2† ]	[−5.4† ]	[0.0988]
	(10.0)	(10.7)	(10.2)	(11.0)	(5.6)	(5.8)		(10.2)	(11.0)	(4.6)	(5.1)
Fat mass (kg)	54.6	53.5	50.4	46.2	−4.2*	−7.3*	0.0005	52.1	48.7	−2.5*	−4.8*	0.0021
	[54.2]	[53.8]	[50.0]	[46.7]	[−4.2† ]	[−7.4† ]	[0.0173]	[51.6]	[49.0]	[−2.5† ]	[−4.8† ]	[0.0540]
	(8.8)	(10.1)	(10.7)	(11.8)	(6.0)	(6.4)		(10.9)	(11.0)	(5.6)	(5.6)
Fat-free mass (kg)	58.3	58.5	58.1	57.3	−0.2	−1.3*	0.0203	58.2	58.0	−0.1	−0.5	0.1319
	[59.0]	[59.1]	[58.8]	[57.8]	[−0.2]	[−1.3† ]	[0.0771]	[58.9]	[58.5]	[−0.1]	[−0.5]	[0.4279]
	(9.7)	(11.7)	(9.7)	(10.7)	(2.9)	(3.2)		(9.0)	(11.2)	(2.6)	(2.9)
Fat-free mass/weight (%)	51.6	52.3	53.7	55.7	+2.1*	+3.4*	0.0039	53.0	54.5	+1.4*	+2.2*	0.0187
	[52.1]	[52.3]	[54.2]	[55.7]	[+2.1† ]	[+3.4† ]	[0.0618]	[53.5]	[54.5]	[+1.4† ]	[+2.2† ]	[0.1759]
	(5.4)	(5.2)	(6.7)	(6.6)	(3.2)	(3.2)		(6.6)	(6.0)	(3.0)	(2.8)
SBP (mm Hg)	124.7	123.4	121.0	119.4	−3.7	−4.0*	0.8032	124.4	123.2	−0.2	−0.2	0.9353
	[124.7]	[123.6]	[121.0]	[119.6]	[−3.7]	[−4.0† ]	[0.7368]	[124.5]	[123.4]	[−0.2]	[−0.2]	[0.8623]
	(13.5)	(13.7)	(11.1)	(13.5)	(11.8)	(13.4)		(12.6)	(14.7)	(9.3)	(10.4)
DBP (mm Hg)	74.0	73.9	73.2	72.0	−0.8	−1.9*	0.4548	73.8	74.7	−0.2	+0.8	0.3545
	[73.9]	[74.1]	[73.1]	[72.2]	[−0.8]	[−1.9† ]	[0.4181]	[73.7]	[74.9]	[−0.2]	[+0.8]	[0.3638]
	(7.3)	(7.7)	(7.8)	(8.5)	(5.7)	(7.0)		(7.6)	(8.8)	(5.4)	(5.3)

Abbreviations: BMI, body mass index; DBP, diastolic blood pressure; FB, reduced-energy, food-based diet; MD, Medifast 5 & 1 Plan; SBP, systolic blood pressure.

^*P <0.05 for within-group difference in change in measure between baseline and week 26 or baseline and week 52 from mixed model analysis of covariance with adjustment for race.

^†P <0.05 for within-group difference in change in measure between baseline and week 26 or baseline and week 52 from mixed model analysis.

^aP value for between-group difference in change in measure at week 26 from mixed model analysis of covariance with adjustment for the relevant baseline measure and ethnicity [p-value in parentheses does not adjust for ethnicity as a covariate].

^bP value for between-group difference in change in measure at week 52 from mixed model analysis of covariance with adjustment for the relevant baseline measure and ethnicity [p-value in parentheses does not adjust for ethnicity as a covariate].

^cMean (adjusted for race).

^dMean (unadjusted).

^eStandard deviation.