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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Heart Rhythm. 2013 Mar 22;10(7):10.1016/j.hrthm.2013.03.023. doi: 10.1016/j.hrthm.2013.03.023

Figure 1.

Figure 1

Effect of GS-458967 (GS967; 10–300 nM) on action potentials (APs) recorded from canine Purkinje fibers. A: Effect of GS967 on AP morphology recorded at basic cycle lengths (BCLs) of 1000, 500, and 300 ms. B: Composite data of the effect of GS967 on the action potential duration measured at 90% repolarization (APD90) and on the maximal rate of rise of the action potential upstroke (Vmax). GS967 (10–300 nM) concentration-dependently reduced APD without reducing Vmax (n = 5). *P < .05 vs control.