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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Heart Rhythm. 2013 Mar 22;10(7):10.1016/j.hrthm.2013.03.023. doi: 10.1016/j.hrthm.2013.03.023

Figure 3.

Figure 3

Rate dependence of early afterdepolarizations (EADs) elicited by exposure to E-4031 in a canine Purkinje fiber and their inhibition by GS-967. A: E-4031 (5 μM) induced EADs at basic cycle lengths (BCLs) of 800, 1000, 1500, and 2500 ms. B: Addition of GS-458967 (GS967; 30 nM) suppressed EADs and triggered activity. C: Addition of GS967 (100 nM) further reduced action potential duration. D: Superimposed traces of the effects of E-4031 and GS967.