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GS-458967 (GS967) abolishes early afterdepolarizations (EADs) and EAD-induced triggered activity elicited by exposure to ATX-II in a canine Purkinje fiber. A: ATX-II (10 nM) elicited EADs and EAD-induced triggered activity at basic cycle lengths (BCLs) of 2000, 2500, 3500, 4500, and 8000 ms. GS967 (30 nM) abolished all EADs and triggered activity.
