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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Heart Rhythm. 2013 Mar 22;10(7):10.1016/j.hrthm.2013.03.023. doi: 10.1016/j.hrthm.2013.03.023

Figure 6.

Figure 6

Effect of GS-458967 (GS967) on delayed afterdepolarizations (DADs) and DAD-induced triggered activity elicited by exposure to high calcium and isoproterenol in a canine Purkinje fiber. A: High calcium (5.4 mM) and isoproterenol (1 μM) induced prominent DADs and DAD-induced triggered activity in a pulmonary vein sleeve preparation following 20 beats at basic cycle lengths (BCLs) of 1000, 800, 500, and 300 ms. B: GS967 (30 nM) markedly reduced DADs and triggered activity. C: GS967 (100 nM) completely abolished all DADs and triggered activity. D: Incidence of DAD-induced triggered activity in 4 Purkinje fibers exposed to high calcium (5.4 mM) + isoproterenol (l μM) alone or in combination with 30 and 100 nM GS967.