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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Heart Rhythm. 2013 Mar 22;10(7):10.1016/j.hrthm.2013.03.023. doi: 10.1016/j.hrthm.2013.03.023

Figure 7.

Figure 7

GS-458967 (GS967) suppresses delayed afterdepolarizations (DADs) and DAD-induced triggered activity elicited by exposure to isoproterenol in a canine pulmonary vein (PV) sleeve preparation. A: Isoproterenol (1 μM) elicited a DAD following 20 beats at a basic cycle length (BCL) of 150 ms and a DAD-induced triggered response after 20 beats at BCLs of 120 or 100 ms. B: GS967 (30 nM) suppressed the triggered response and markedly reduced DAD activity. C: Incidence of DAD-induced triggered activity in 4 PV sleeve preparations exposed to high calcium (5.4 mM) + isoproterenol (l μM) alone or in combination with 30 and 100 nM GS967.