Table 3.

Hazard ratio of baseline CR in APOE ε2 carriers and non-carriers. Both models were adjusted for baseline age, gender, and ε4 carrier status.

Variable	N	Hazard Ratio (95% CI)	p-value
CR in ε2 carriers (ε2/ε2 and ε2/ε3)	30	0.09 (0.01 – 0.75)	.03
CR in ε2 non-carriers (ε3/ε3)	140*	0.53 (0.37 – 0.77)	.001

Abbreviations: CR = cognitive reserve composite score.

^*The sample size for the ε2 non-carrier group represents the individuals who were ε3/ε3 (n = 140), since the model was adjusted for ε4 carrier status (n = 87).