Table 1.
Variables stratified by good vs. poor baseline leptomeningeal collateral status on CT-angio (n=206). * Lab parameters measured at presentation.
| Good Leptomeningeal Collaterals ( rLMC score 11-20) (n=133) |
Poor Leptomeningeal Collaterals (rLMC score 0-10) (n=73) |
p value | |
|---|---|---|---|
| Demographics | |||
| Age (in yrs, mean+/− SD) | 65.6 +/− 12.2 | 69.1 +/− 10.1 | 0.04 |
| Sex (male, %) | 54.90% | 47.90% | 0.38 |
| Baseline Clinical Measurements | |||
| Height in cm (IQR) | 163 (14) | 162.5 (13) | 0.84 |
| Weight in Kg (IQR) | 60 (11) | 60 (13) | 0.34 |
| Waist in cm (IQR) | 82 (12) | 81 (23) | 0.96 |
| Body Mass Index in kg/m2 (IQR) | 22.5 +/− 4 | 22.9 +/− 3.02 | 0.38 |
| Systolic Blood Pressure +/− SD (mmHg) | 136.5 +/− 27.2 | 143.1 +/− 29.2 | 0.11 |
| Diastolic Blood Pressure +/− SD (mm Hg) |
82.7 +/− 12.8 | 83.6 +/− 13.5 | 0.63 |
| Temperature (IQR) (celsius) | 36.4 (0.6) | 36.2 (0.5) | 0.01 |
| Onset to CT time (median, IQR) (mins) | 137.5 (147.5) | 136.0 (119) | 0.19 |
| Pre-morbid Risk Factors | |||
| Hypertension (%) | 47.4% | 64.4% | 0.02 |
| Coronary arterial disease (%) | 34.2% | 24.8% | 0.19 |
| Diabetes mellitus (%) | 27% | 37.0% | 0.15 |
| Smoking (%) | 34.1% | 31.5% | 0.41 |
| Previous stroke/TIA (%) | 18.6% | 23.3% | 0.27 |
| Laboratory Studies | |||
| Blood Glucose +/−SD (mg/dL)* | 133.1+/− 48.1 | 164.5 +/− 95.5 | <0.01 |
| Hemoglobin in g/dL* (IQR) | 13.2 (2.1) | 13.7 (2.2) | 0.08 |
| Hematocrit (%)* | 38.4 (7.3) | 40.3 (6.2) | 0.07 |
| WBC count in cells/mL* (IQR) | 7780 (3280) | 8460 (3940) | 0.02 |
| Platelet count in cells per mL* (IQR) | 235000 (93,000) | 230000 (72,000) | 0.27 |
| ESR mm/hr* (IQR) | 11 (14) | 12 (17) | 0.98 |
| CRP in mg/L* (IQR) | 0.38 (1.01) | 0.38 (1.17) | 0.85 |
| INR IU* (IQR) | 1 (0.12) | 1 (0.12) | 0.29 |
| D-dimer mcg/mL (IQR) | 1 (2.1) | 2.25 (4.2) | <0.01 |
| Serum Fibrinogen mg/dL (IQR) | 253 (103) | 268 (99) | 0.18 |
| Serum Homocysteine μmol/L (IQR) | 10.52 (5.7) | 11.02 (5.7) | 0.46 |
| Serum Uric acid mg/dL (IQR) | 4.8 (2.5) | 5.3 (2.2) | <0.01 |
| Total Cholesterol mg/dL (IQR) | 175 (64) | 180 (42) | 0.38 |
| Triglycerides mg/dL (IQR) | 83.8 (59.1) | 90.6 (47.5) | 0.15 |
| HDL-C mg/dL (IQR) | 45.3 (14.5) | 46.1 (13.9) | 0.73 |
| LDL-C mg/dL (IQR) | 103.5(52.3) | 117.3 (29.8) | 0.09 |
| Metabolic Syndrome | 21.50% | 46.60% | <0.01 |
| Outcomes | |||
| mRS 0-2 at 90 days | 40.60% | 19.20% | <0.01 |
rLMC score indicates regional leptomeningeal collateral score; IQR, Interquartile Range; SD, Standard Deviation; WBC, White Blood Cell; mL, milliliter; ESR, Erythrocyte sedimentation rate; CRP, C-reactive protein; INR, International Normalized Ratio; mcg, microgram; mg, milligram; dL, deciliter; μmol, micro-mole; L, liter; HDL, High density lipoprotein; LDL, Low density lipoprotein; mRS, modified Rankin Scale.