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. 2013 Nov 21;8(11):e79432. doi: 10.1371/journal.pone.0079432

Figure 1. Effect of Citrobacter rodentium (CR) infection on gross morphology.

Figure 1

H&E staining in the paraffin-embedded sections prepared from the distal colons of uninfected normal (N) and CR infected (days 3–19) C57Bl/6 (A) and Tlr4−/− (C) mice, respectively. Scale bar, 100 µm. Crypt hyperplasia as measured by Ki-67 staining. Immunohistochemical labeling of Ki-67 as a marker of proliferation in paraffin-embedded sections prepared from the distal colons of uninfected normal (N) and CR-infected (days 3–19) C57Bl/6 (B) and Tlr4−/− (D) mice, respectively. Percentages represent percent cells positive for Ki-67. Scale bar = 100 µm (n = 3 independent experiments).