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. 2013 Nov 21;8(11):e80129. doi: 10.1371/journal.pone.0080129

Table 2. Comparison of Inline graphic and KEGG pharmacological information.

Methods Data Sources Kernels Inline graphic or C AUC
KL1LR STITCH DDIPharm 0.04 0.7508
KL1LR STITCH Pharmacology 0.04 0.7369
KL1LR KEGG DDIPharm 0.04 0.7316
KL1LR KEGG Pharmacology 0.03 0.7232
SVM STITCH DDIPharm 2 0.7982
SVM STITCH Pharmacology 0.75 0.7685
SVM KEGG DDIPharm 30 0.6727
SVM KEGG Pharmacology 20 0.7089

Two sets of drug-target interactions from STITCH and KEGG were used for prediction. Inline graphic and Inline graphic are the KL1LR and SVM parameters, respectively; Table S1 contains prediction results when different parameter values were used. Table S2 contains ROC curves of true positive rate and false positive rate, and tables of true positive, false positive, true negative, and false negative values for each threshold.