Figure 5. Importance of the α7nAChR on T cells in imiquimod-induced skin allograft rejection.

Lymphopenic female Rag−/− mice were reconstituted with 8×10⁶ CD90+ T cells (containing both CD4+ and CD8+ T cells) purified from either α7+/+ or α7−/− female mice. Reconstituted mice were transplanted with a male skin graft harvested from male Rag−/− mice and imiquimod was applied for days 10 to 15. Skin graft survival in both conditions is shown.