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. 2013 Nov 21;7(11):e2564. doi: 10.1371/journal.pntd.0002564

Figure 4. Transport activities of uracil and 5-fluorouracil in L. infantum wild-type cells and 5-FU resistant mutants.

Figure 4

(A). Transport of 5-fluorouracil (black squares) and uracil (black triangles) in L. infantum WT cells and in Lin5FU500.4 mutant cells (5-fluorouracil (white squares) and uracil (white triangles)) after 1, 2, 5 and 10 minutes (B). Transport of [3H]-uracil (white bars) competed with 200× (grey bars) or 2000× ratio (black bars) of cold uracil (left panel) or 5-FU (right panel) after a 10 minutes incubation period. (C). Accumulation of [3H]-5-fluorouracil in L. infantum WT 263 strain and in the 5-FU mutants after 10 minutes. Average of three independent biological replicates. * (p<0.05).