Table 3. Resistance to 5-fluorouracil in 5-FU resistant mutants genetically complemented with WT alleles.

	5FU EC50 (µM)
L. infantum 263 WT+pSP72αHYGα	29±7
+pSP72αHYGα/LinJ.10.1090 (UP)	14±3
+pSP72αHYGα/LinJ.21.1450 (TK)	67±23
+pSP72αHYGα/LinJ.34.1110 (UPRT)	17±2
L. infantum 5FU500.3+pSP72αHYGα	>2000
+pSP72αHYGα/LinJ.10.1090	>2000
+pSP72αHYGα/LinJ.21.1450	136±13
+pSP72αHYGα/LinJ.34.1110	>2000
L. infantum 5FU500.4+pSP72αHYGα	>2000
+pSP72αHYGα/LinJ.10.1090	31±8
+pSP72αHYGα/LinJ.21.1450	>2000
+pSP72αHYGα/LinJ.34.1110	1140±285
L. infantum 5FU500.5+pSP72αHYGα	>2000
+pSP72αHYGα/LinJ.10.1090	22±3
+pSP72αHYGα/LinJ.21.1450	>2000
+pSP72αHYGα/LinJ.34.1110	>2000