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. 2013 Nov 21;8(11):e74502. doi: 10.1371/journal.pone.0074502

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© 2013 Dzinic et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Benign tumor or better differentiated cancer with better prognosis is associated with nuclear maspin. Nuclear maspin has a stronger affinity towards HDAC1 as compared to hypothetical HDAC1-associated nuclear factor X. (B) High grade carcinoma exhibiting a less differentiated phenotype and worse prognosis is associated with cytosolic maspin or loss of maspin. In cancer, hypothetical HDAC1- associated nuclear factor X is X′ and it has a stronger affinity towards HDAC1 as compared to maspin. (C) Therapeutic potential of bioengineered maspin mutant or its derivative in treating advanced disease. Maspin mutant restores maspin nuclear localization and HDAC1 inhibition in advanced disease.