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. 2013 Nov 16;62(12):4257–4265. doi: 10.2337/db13-0420

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© 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — QT prolongation of Ins2^Akita (Akita) and db/db hearts and reversal by mexiletine. Cardiac electrical activity was recorded from spontaneously beating hearts mounted on a Langendorff apparatus. QT intervals corrected for heart rate (QTc) were automatically calculated from the tracings using the Mitchell formula (15). A: Representative tracings from Akita and wild-type (WT) hearts. Hearts were treated with insulin (1 unit/L), PI-103 (500 nmol/L), or mexiletine (4 μg/mL) added to the perfusate. Summary QTc graph shows mean ± SE (bottom right). n ≥ 4 hearts per group. *, significantly different from WT values (P < 0.05, ANOVA with post hoc Fisher least significant differences test). B: Representative tracings from a db/db heart before and after mexiletine treatment. Summary QTc graph shows mean ± SE (right). n = 5 hearts. *, significantly different from before values (P < 0.05, Student t test).