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. 2013 Nov 16;62(12):4132–4143. doi: 10.2337/db13-0097

FIG. 7.

FIG. 7.

Effects of PDCD4 deficiency on LXR-α expression and ER homeostasis in WAT. Epididymal adipose tissues were collected from WT and PDCD4−/− mice fed a ND or HFD for 24 weeks. The expression of LXR-α and its target genes, as well as ER stress markers, were examined. (A) Representative Western-blot of LXR-α in epididymal adipose tissues (n = 3 mice/condition). (B) mRNA levels of LXR-α in epididymal adipose tissues (n = 12 WT mice or 8 PDCD4−/− mice). mRNA levels and (H) representative Western-blot of (C) SREBP-1c, (D) FAS, (E) SCD1, (F) ABCA1, and (G) ABCG1 in epididymal adipose tissues (n = 4–9 mice/group). (I) Representative Western-blot of ER stress markers in epididymal adipose tissues (n = 3 mice/condition). Data are presented as mean ± SEM. GADPH, glyceraldehyde-3-phosphate dehydrogenase; XBP, X-box binding protein. *P < 0.05, **P < 0.01, ***P < 0.001.