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. 2013 Nov 16;62(12):3990–3992. doi: 10.2337/db13-1314

FIG. 1.

FIG. 1.

Schematic showing potentially informative tests for tracking the loss of β-cell mass and function. Deterioration of FPIR in the IVGTT and of OGTT responses are currently the best indicators of impending diabetes. Imaging methods for monitoring β-cell mass are still in development. Little is known about the pattern of insulitis and decline in β-cell mass in humans during the prediabetic prodrome. PI/C-peptide, proinsulin-to-C-peptide ratio; Teff, effector T cells.