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. 2013 Oct 9;288(47):33873–33883. doi: 10.1074/jbc.M113.497701

FIGURE 1.

FIGURE 1.

Genetic analysis. A, denaturing HPLC analysis of CACNA1A, exon 19. Chromatograms at 68 °C shows different profiles corresponding to wild type and variant samples. B, Sanger sequence analysis of CACNA1A exon 19, showing a sample heterozygous for the c. 3043G>A (E1015K) variant. C, Family 1 pedigree and segregation of the variant with the hemiplegic migraine phenotype. D, Family 2 pedigree. Segregation analysis was not feasible. Black symbol, hemiplegic migraine; gray symbol, migraine without aura; hatched symbol, common headache; plus (+) sign indicates a subject heterozygous for the E1015K variant; minus (−) sign indicates a subject without the variant.