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Schematic of a diverse range of signaling pathways that can lead to persistent PKC activation to support cell migration. Three Raf proteins activated through three different mechanisms can activate RFFL transcription via an ERK-MYC pathway, which leads to persistent mTORC2-mediated PKC HM phosphorylation and activation. Persistent PKC activation is important for sustaining the migration of fibroblasts and tumor cells. BRAF*, activated BRAF; ub, ubiquitin.
