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Conserved inter-domain interface in the MHCII molecule HLA-DQ8 (1JK8) that maintains the inter-domain orientation for CD4-binding. (A) The overall view of HLA-DQ8. The gold color indicates the α chain whereas the cyan color defines the β chain. (B) Zoomed-in view of detailed inter-domain interaction involving particularly W153 at the β chain’s DE loop (in yellow) and Y150 on the α chain’s E strand (in light brown).
