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Superposition of the HLA-DM structure onto the DR1-CD4 complex. The superposition is based on the α2 domain. HLA-DM’s α2 domain is in green, whereas the β2 domain is in cyan. Note that DM’s β2 domain does not have a D-strand for pairing to CD4’s C″-strand necessary for docking, a key feature of CD4-binding to all MHCII molecules. In addition, DM’s AB loop protrudes, thereby colliding with CD4.
