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. 2013 Nov 22;4:383. doi: 10.3389/fimmu.2013.00383

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Copyright © 2013 Li, Teng, Reinherz and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structure of mouse CD8αβ in complex with the MHCI molecule H-2D^d. (A) An overview of the complex. (B) Details of the binding region. Note that the key conserved Q226 from MHCI molecule’s CD loop pokes into a crevice formed between CD8α and β subunits, making hydrogen bonds to conserved S37 of the CD8α subunit, while the aliphatic portion of this Q226 is involved in extensive hydrophobic contacts with the conserved Y55 of the CD8α subunit.