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. 2013 Nov 22;7:174. doi: 10.3389/fnbeh.2013.00174

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Copyright © 2013 Albuquerque, Häussler, Vannoni, Wolfer and Tegeder.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nociceptive behavior and motor functions in C57BL6/J and progranulin deficient (Grn^−/−) mice before and after injury of the sciatic nerve in the Spared Nerve Injury (SNI) model. (A–C) Time course of the nociceptive behavior upon mechanical, heat and cold stimulation before and after SNI in young C57BL6/J and progranulin deficient (Grn^−/−) mice. (D) RotaRod running behavior before and after SNI. (E) Nociceptive behavior at the end of the IntelliCage experiments after sham or SNI surgery in young and aged C57BL6/J and progranulin deficient mice. The asterisks (^*) denote significant differences between the respective SNI and sham treated mice, and the crosses (#) show significant differences between genotypes, P < 0.05. Data are means ± s.e.m. of n = 8–12 per group for all tests.