Figure 5.

Place “preference learning” and “reversed place preference learning” in young and aged C57BL6/J and progranulin deficient (Grn^−/−) mice. (A) Illustration of the place preference learning and reversal tasks. The blue circles indicate nosepokes where a water award was provided. The crossed circles show non-awarding nosepokes, i.e., water access was blocked, without punishment. (B,C) Time courses of nosepoke error percentages (mean ± s.e.m) per day in C57BL6/J and progranulin deficient (Grn^−/−) mice, n = 8 per group, during place preference learning and reversed learning. rm-ANOVA revealed significant differences between young and aged mice in both genotypes, P < 0.05, n = 8 per group. Time points which differed significantly vs. the sham treated young mice are indicated per asterisks, P < 0.05.