Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Nov 22;7:210. doi: 10.3389/fncel.2013.00210

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2013 Münster-Wandowski, Gómez-Lira and Gutiérrez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The pharmacologically isolated GABAergic synaptic currents evoked by stimulation of MFBs have the signature of transmission of MF origin. (A) Schematic depiction of an isolated pyramidal cell with a fluorescent MF bouton on the apical dendrite and an interneuronal bouton on the basal dendrite. A bipolar theta glass pipette was used for stimulation of the boutons. Changing the stimulation frequency from 0.05 to 1 Hz produced a strong potentiation (>200%) of the GABAergic synaptic responses (black circles). By contrast stimulation of IntBs (open circles) produced frequency-dependent depression. (B) The effect of L-AP4 on the pharmacologically isolated GABAergic current evoked by MF bouton stimulation is presynaptic, as evidenced by the paired-pulse protocol. By contrast, GABAergic responses evoked by interneuronal bouton stimulation were unaffected. (C) Group synaptic responses to MF bouton (black circles; n = 6) and interneuronal bouton stimulation (open circles; n = 6). Responses to MF bouton stimulation were partially blocked by iGluR blockers. The remaining responses were strongly and reversibly depressed by the activation of mGluRs with L-AP4, and completely blocked by bicuculline. Responses to interneuronal bouton stimulation were not affected by the perfusion of iGluR blockers, but completely blocked by bicuculline (from Beltrán and Gutiérrez, 2012).