Table 1. The cytotoxicity (IC50) of PPE-based micelles and SCKs, and some commonly utilized delivery vehicles, such as, Lipofectamine, PEI and Cremophor-EL in RAW 264.7 mouse macrophages. The cytotoxicity of the degradation products of PPE-nanoparticles and their PEBP-b-PBYP backbone are also included. Values are presented as mean ± SD of at least triplicates.
| Controls | IC50 (μg/mL) ± SD | PPE-Micelles | IC50 (μg/mL) ± SD | PPE-SCKs | IC50 (μg/mL) ± SD | PPE-Deg | IC50 (μg/mL) ± SD |
|---|---|---|---|---|---|---|---|
| Lipofectamine | 31.4 ± 6 | Anionic micelles | 1705 ± 16 | Anionic SCKs | 761 ± 38 | Anionic micelles-Deg | * |
| PEI | 4.3 ± 1 | Cationic micelles | 180 ± 48 | Cationic SCKs | * | Cationic micelles-Deg | * |
| Cremophor-EL | 1700 ± 113 | Zwitterionic micelles | * | Zwitterionic SCKs | * | Zwitterionic micelles-Deg | * |
| Non-ionic micelles | * | Non-ionic micelles-Deg | * | ||||
| Anionic SCKs-Deg | * | ||||||
| Cationic SCKs-Deg | * | ||||||
| Zwitterionic SCKs-Deg | * | ||||||
| PEBP-b-PBYP-Deg | * |
*The IC50 values could not be determined because high cell-viabilities were observed over the range of the tested concentrations, up to 3000 μg/mL.