Table 1.

General and Histological Signatures of Rodent Aberrant Crypt Foci (ACF).

Characteristic		Type of ACF
	Non-Dysplastic	Hyperplastic	Dysplastic	Reference
Darker staining	Yes	Yes	Darkest	[29,30]
Size	Increased	Increased	Increased	[29,31]
Topography	Raised	Raised	Raised	[31]
Diameter	Widest	Wide	Wide	[21,30,32]
Dilated lumen	Yes	Mixed	Thickened and closing	[30,31]
Pericryptal area	Serrated	Mixed	Non-serrated	[6,21,33]
Mucin status	Present	Mildly depleted	Depleted	[33,34,35,36,37]
Polarity	Ordered	Mixed	Lost	[29]
Nuclear morphometry	Round & non-stratified	Mixed	Oval & stratified	[21,29,30]
Proliferation pattern	Lower two-thirds of crypt	Progression to upper crypt	Full progression throughout crypt	[8,38]