TABLE 4.

Univariate analysis of prognostic factors

Characteristic	Overall survival		Local recurrence-free survival		Distant recurrence-free survival
	HR (95 % CI)	P	HR (95 % CI)	P	HR (95 % CI)	P
Age (scaled by 0.1)	1.80 (1.25–2.58)	0.002	1.28 (0.85–1.92)	0.231	0.88 (0.59–1.30)	0.520
Age ≥62 y (median)a	3.68 (1.30–10.40)	0.014	3.27 (0.85–12.60)	0.084	0.88 (0.27–2.88)	0.829
Grade (3 categories)	2.03 (0.95–4.33)	0.069	1.27 (0.54–2.99)	0.582	2.92 (0.80–10.70)	0.106
Negative margin statusb	1.18 (0.48–2.94)	0.718	4.34 (1.15–16.40)	0.030	0.70 (0.20–2.41)	0.573
R status	1.26 (0.49–3.26)	0.632	3.08 (0.94,10.09)	0.064	1.01 (0.26–3.85)	0.993
Site (LE vs. other)	2.12 (0.81–5.59)	0.128	0.72 (0.22–2.37)	0.593	4.43 (0.96–20.55)	0.057
Tumor size	1.12 (1.04–1.21)	0.004	1.01 (0.87–1.16)	0.924	1.16 (1.05–1.29)	0.004
Receipt of chemotherapyc	0.92 (0.27–3.14)	0.888	1.18 (0.25–5.53)	0.836	3.50 (1.01–12.07)	0.048
Receipt of radiotherapyc	0.46 (0.18–1.16)	0.100	0.43 (0.12–1.51)	0.187	3.15 (0.68–14.61)	0.142

HR hazard ratio, CI confidence interval

^aAge modeled as a dichotomous variable of < 62 y or ≥62 y

^bModeled as negative vs. close/positive

^cModeled as time-dependent variables