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. 2008 Nov 24;284(5):3306–3313. doi: 10.1074/jbc.M803658200

FIGURE 4.

FIGURE 4.

Global fitting of the original random bi-bi model including AMP and free ATP inhibition. From the figure we can see that the conventionally accepted model (a) cannot generate a fit if we perform a global fitting of multiparameters. Even when we modify the model to include Mg2+ activation at rapid equilibrium, the fitting results stay more or less unchanged (b). See supplemental materials for detailed model definitions and equations.