Table 2.
Incidence Rates and Adjusted Hazard Ratios (95% CIs) of Clinical Outcomes for those who were Reclassified by the CKD-EPI Equation Compared with those not Reclassified in General Population Cohorts
| All-cause mortality (61,426 events) |
Cardiovascular mortality (16,923 events) |
ESRD (666 events) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| MDRD eGFR category (ml/min/1.73 m2) |
Upward re- classification (5,586 events) |
No re- classification (53,601 events) |
Downward re- classification (2,239 events) |
Upward re- classification (1,113 events) |
No re- classification (14,979 events) |
Downward re- classification (831 events) |
Upward re- classification (60 events) |
No re- classification (588 events) |
Downward re- classification (18 events) |
| 90+ | |||||||||
| Crude incidence rate (per 1,000 person-years) |
- | 3.8 | 52.9 | - | 0.8 | 22.3 | - | 0.3 | 0.4 |
| Adjusted hazard ratio | - | reference | 1.02 (0.89-1.18) |
- | reference | 1.24 (1.01-1.53) |
- | reference | 1.54 (0.50-4.78) |
| 60-89 | |||||||||
| Crude incidence rate (per 1,000 person-years) |
2.2 | 10.2 | 95.1 | 0.4 | 3.0 | 46.0 | 0.1 | 0.2 | 2.3 |
| Adjusted hazard ratio | 1.03 (0.98-1.08) |
reference | 0.98 (0.85-1.14) |
0.93 (0.85-1.02) |
reference | 1.21 (1.01-1.43) |
0.47 (0.24-0.93) |
reference | 4.44 (1.52-13.00) |
| 45-59 | |||||||||
| Crude incidence rate (per 1,000 person-years) |
9.9 | 34.5 | 111.6 | 2.7 | 13.0 | 52.3 | 0.5 | 0.8 | 1.6 |
| Adjusted hazard ratio | 0.80 (0.74-0.86) |
reference | 1.15 (1.03-1.27) |
0.73 (0.65-0.82) |
reference | 1.25 (1.07-1.48) |
0.49 (0.27-0.88) |
reference | 2.67 (0.73-9.72) |
| 30-44 | |||||||||
| Crude incidence rate (per 1,000 person-years) |
18.2 | 66.4 | 134.5 | 6.0 | 27.3 | 56.4 | 4.6 | 7.0 | 13.7 |
| Adjusted hazard ratio | 0.74 (0.61-0.88) |
reference | 1.11 (0.79-1.55) |
0.75 (0.54-1.05) |
reference | 1.25 (0.68-2.31) |
0.95 (0.43-2.07) |
reference | 1.35 (0.51-3.56) |
| 15-29 | |||||||||
| Crude incidence rate (per 1,000 person-years) |
33.4 | 88.1 | - | 15.7 | 33.6 | - | 59.5 | 59.7 | - |
| Adjusted hazard ratio | 1.04 (0.51-2.15) |
reference | - | 1.66 (0.44-6.30) |
reference | - | 1.13 (0.36-3.54) |
reference | - |
Abbreviations: CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; MDRD, Modification of Diet in Renal Disease; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease.
Adjusted for age, gender, race/ethnicity, smoking, systolic blood pressure, total cholesterol, diabetes, history of cardiovascular disease, body mass index, and albuminuria.