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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Ann Neurol. 2013 Mar 14;73(5):10.1002/ana.23868. doi: 10.1002/ana.23868

Figure 6. Schematic representation of the potential mechanisms by which group 1 mGluR and GRK2 mediate IL-1β-induced sensitization.

Figure 6

The diagram depicts the molecular mechanisms leading to excitotoxic neuronal cell death in the absence (A) or presence (B) of IL-1β sensitizing effect. In the absence of IL-1β, GRK2 leads to a rapid desensitization of mGlu1/5, limiting the PLCβ1-mediated calcium release from endogenous stores. Exposure to IL-1β leads to a reduced content of GRK2, preventing the complete desensitization of mGlu1/5 and allowing a more prolonged calcium release from endogenous stores. This enhanced calcium mobilization exacerbates neuronal cell death. E.R., endoplasmic reticulum.