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. Author manuscript; available in PMC: 2013 Nov 22.
Published in final edited form as: Cancer Res. 2012 Aug 8;72(19):10.1158/0008-5472.CAN-12-1248. doi: 10.1158/0008-5472.CAN-12-1248

Figure 1.

Figure 1

Hh pathway is activated in tamoxifen-resistant breast cancer cells. A and B, real-time RT-PCR (A) and Western blot analysis of SHH, SMO, GLI1, and PTCH in MCF7 and OHTR cells (T100: OHTR100, T500: OHTR500, T1000: OHTR1000; B) quantified in the bar diagram. C, Western analysis and quantification of Hh markers in ER-positive cell lines. D and E, GLI-driven luciferase expression in MCF7 and OHTR cells (D) and after depletion of GLI1 in OHTR1000 cells (E). F and G, real-time RT-PCR (F) and Western analysis (G) of Hh target genes in MCF7 and OHTR cells quantified in the bar diagram.