Table 4.
Single Variant Assocation Analysis Genotyped SNPs with Low HDL-C and High TG
| |
|
|
Low HDL-C |
High TG |
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|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Genotype categories | Genotype counts cases (%) | Genotype counts controls (%) | P1(allelic2, genotypic3) | Genotype counts cases (%) | Genotype counts controls (%) | P1 (allelic2, genotypic3) |
| ABCA1 | rs1800977 | CC | 22 (48.9) | 141 (44.8) | (0.278, 0.283) | 23 (48.9) | 140 (44.7) | (0.674, 0.867) |
| CT | 22 (48.9) | 144 (45.7) | 20 (42.6) | 146 (46.6) | ||||
| TT | 1 (2.2) | 30 (9.5) | 4 (8.5) | 27 (8.7) | ||||
| LPL | rs328 | SX | 6 (13.3) | 63 (20.0) | (0.315, 0.197) | 6 (12.8) | 63 (20.1) | (0.258, 0.232) |
| SS | 39 (86.7) | 252 (80.0) | 41 (87.2) | 250 (79.9) | ||||
| CETP | rs708272 | B1B1 | 18 (40.0) | 90 (28.6) | (0.020, 0.046) | 14 (29.8) | 94 (30.0) | (0.985, 0.996) |
| B1B2 | 23 (51.1) | 151 (47.9) | 23 (48.9) | 151 (48.2) | ||||
| B2B2 | 4 (8.9) | 74 (23.5) | 10 (21.3) | 68 (21.8) | ||||
| LIPC | rs1800588 | CC | 26 (57.8) | 218 (69.2) | (0.356, 0.096) | 32 (68.1) | 212 (67.7) | (0.680, 0.265) |
| CT | 19 (42.2) | 86 (27.3) | 12 (25.5) | 93 (29.7) | ||||
| TT | 0 (0) | 11 (3.5) | 3 (6.4) | 8 (2.6) | ||||
| SHBG | rs1799941 | AA | 0 (0) | 8 (2.5) | (0.254, 0.648) | 1 (2.1) | 7 (2.2) | (0.393, 0.549) |
| AG | 10 (22.2) | 83 (26.3) | 15 (31.9) | 78 (24.9) | ||||
| GG | 35 (77.8) | 224 (71.2) | 31 (66.0) | 228 (72.8) | ||||
| rs6257 | CC | 0 (0) | 4 (1.3) | (0.130, 0.143) | 1 (2.1) | 3 (1.0) | (0.116, 0.169) | |
| CT | 21 (46.7) | 98 (31.1) | 20 (42.6) | 99 (31.6) | ||||
| TT | 24 (53.3) | 213 (67.6) | 26 (55.3) | 211 (67.4) | ||||
1
Chi-Square or Fisher's Exact test p value is presented where appropriate for indicated test, either allelic or genotypic.
2
Allelic test: Compares the frequencies of alleles at the specified marker in cases versus controls using a Chi-Square test with 1 degree of freedom; M versus m (M=major allele, m=minor allele).
3
Genotypic test: Compares the frequencies of genotypes at a specifed marker in cases versus controls using a Chi-Square test with 2 degrees of freedom; MM versus Mm versus mm (M=major allele, m=minor allele).