Table 9.
Quantitative Multifactor Dimensionality Reduction (qMDR) Analysis of HDL-C in Full Dataset
| Model1 | Training T-statistic2 | Testing T-statistic3 | CVC4 | P5 |
|---|---|---|---|---|
| rs708272 | 2.644 | 2.133 | 8/10 | 0.034 |
| rs1800977 – rs6257 | 3.338 | 1.586 | 4/10 | 0.114 |
| rs1800977 – rs708272 – rs6257 | 4.445 | 0.363 | 6/10 | 0.717 |
| rs1800977 – rs708272 – rs328 – rs6257 | 5.581 | 0.251 | 3/10 | 0.802 |
1
Defines the genetic single or multi-locus model being analyzed; 2Students t-statistic based on comparison of HDL-c measurments between high and low risk groups defined by selected SNP(s) genotype in the training dataset; 3Students t-statistic cased on comparison of HDL-c measurments between high and low risk groups defined by selected SNP(s) genotype in the testing dataset; 4Cross Validation Consistency of the selected model;
5
Empirical p value calculated from the Student's t probablity distribution using the Testing t-statistic and 359 degrees of freedom.