Table 4.

Hazard ratios for CHD events by level of urinary albumin to creatinine ratio among participants without and with CHD at baseline stratified by race.^†

Without CHD at baseline
ACR, mg/g	< 10	10 – 29.99	30–300	> 300	P for interaction*
Age, sex, region adjusted hazard ratio (95% CI)
Whites (n=13,526)	1 (ref)	1.45(1.13–1.86)	1.76(1.30–2.39)	2.98(1.66–5.35)	0.03
Blacks (n= 9,747)	1 (ref)	2.17(1.58–2.97)	3.27(2.37–4.50)	6.14(4.11–9.18)
Multivariable-adjusted hazard ratio†† (95% CI)
Whites (n=13,526)	1 (ref)	1.23(0.96–1.59)	1.19(0.86–1.64)	1.49(0.80–2.76)	0.03
Blacks (n= 9,747)	1 (ref)	1.84(1.34–2.53)	2.40(1.72–3.36)	3.21(2.02–5.09)

With CHD at baseline
ACR, mg/g	< 10	10 – 29.99	30–300	> 300	P for interaction*
Age, sex, region adjusted hazard ratio (95% CI)
Whites (n=3,236)	1 (ref)	1.53(1.17–2.01)	2.32(1.74–3.08)	4.50(3.08–6.57)	0.39
Blacks (n=1,698)	1 (ref)	1.07(0.67–1.70)	1.84(1.21–2.82)	2.74(1.64–4.58)
Multivariable-adjusted hazard ratio†† (95% CI)
Whites (n=3,236)	1 (ref)	1.27(0.96–1.67)	1.54(1.13–1.67)	2.45(1.59–3.77)	0.53
Blacks (n= 1,698)	1 (ref)	1.05(0.66–1.69)	1.73(1.11–2.69)	2.16(1.18–3.95)*

^†Baseline CHD is defined as history of self-reported myocardial infarction (MI), coronary artery bypass graft, angioplasty, stenting, or evidence of MI via electrocardiograph.

^††Multivariable adjustment includes age, sex, geographic region of residence, income, education, health insurance coverage, waist circumference, systolic blood pressure, total and HDL-cholesterol, triglycerides, estimated glomerular filtration rate, C-reactive protein, diabetes, smoking status, physical activity, use of HMG-CoA reductase inhibitors, use of any antihypertensive medications, use of angiotensin II receptor blockers or angiotensin converting enzyme inhibitors and regular aspirin use.

^*P-values for interaction were obtained using a post-estimation Wald test to generate an omnibus P-value for the interaction term between ACR categories and race.