Figure 5. NIS expression is correlated with MEK/ERK activation in human breast tumors.

Immunohistochemical analysis showed that the majority of human breast tumors that were positive for pERK were also positive for NIS, whereas the majority of those breast tumors that were negative for pERK were also negative for NIS. Immunohistochemical staining for pERK (a-d) and corresponding NIS proteins (e-h) in four representative breast cancer specimens are shown. Magnification = 400X.