Figure 6. Fluvastatin treatment improves health in 129.Mecp2^tm1.1Bird/+ females.

a) No fluvastatin-treated 129.Mecp2^tm1.1Bird/+ females died prior to eight months, but three vehicle-treated females died. b) Rotarod performance improves in five-month-old fluvastatin-treated 129.Mecp2^tm1.1Bird/+ females (p=.001). c) Open field activity assessed at four months shows no significant differences in fluvastatin- or vehicle-treated groups. d) Fluvastatin treatment does not significantly change serum cholesterol levels at eight months. e) Fluvastatin treatment ameliorates elevated lipid concentration in 129.Mecp2^tm1.1Bird/+ livers assessed at eight months (p=.045). All error bars represent s.e.m.