Table 4.
Systematic Review of the Data Available on the Susceptibility of Leishmania Species and Isolates to HIV PIs.
| nelfinavir | saquinavir | Ref. | |||
|---|---|---|---|---|---|
| inhibition | conc. | inhibition | conc. | ||
|
L. amazonensis (MHOM/BR/77/LTB016) |
50% (48h) | 15.12 | Virtually no inhibition1 | [62] | |
|
L. amazonensis (MHOM/BR/77/LTB016) |
95% (72h) | 25 | 5% | 25 | [106] |
|
L. amazonenzis (IFLA/BR/67/PH8) |
50% 3 | 13.36 | 50% 3 | 40 | [63] |
|
L. major (LRC-L137) |
49% (24h) | 6.25 | [59] | ||
|
L. major (MHOM/SU/73/5-ASKH) |
50% 3 | 13.37 | 50% 3 | 46.95 | [63] |
|
L. major (MHOM/IL/1980/FRIEDLIN) |
50% (72h) | 25 | 21.2% (72h) | 25 | [106] |
|
L. infantum (MHM/TN/80/IPT1) |
31% (24h) | 50 | [59] | ||
|
L. infantum (MHOM/MA/67/ITMAP-263) |
Virtually no inhibition2 | Virtually no inhibition2 | [61] | ||
|
L. infantum (MHOM/FR/78/LEM-75) |
50% 3 | 16.46 | 50% 3 | 53.97 | [63] |
|
L. infantum (MCAN/ES/98/LLM-724) |
50% 3 | 17.59 | 50% 3 | 50.87 | [63] |
|
L. infantum (MCAN/VE/98/IBO-78) |
50% 3 | 14.05 | 50% 3 | 55.12 | [63] |
|
L. infantum (MHOM/ES/95/LLM-480) |
50% 3 | 18.21 | 50% 3 | 48.04 | [63] |
|
L. infantum (MHOM/ES/98/LLM-759)4 |
50% 3 | 26.89 | 50% 3 | 64.464 | [63] |
|
L. infantum (MHOM/BR/1974/PP75) |
96.2% (72h) | 25 | 0% (72h) | 25 | [106] |
|
L. infantum (MHOM/BR/2009/ANC)4 |
96.6% (72h) | 25 | 0.4% (72h) | 25 | [106] |
|
L. infantum (MHOM/BR/2009/LCS)4 |
96.3% (72h) | 25 | 0% (72h) | 25 | [106] |
|
L. infantum (MHOM/BR/2009/VCF)4 |
0% (72h) | 25 | 0% (72h) | 25 | [106] |
| L. donovani (MHOM/IN/80/DD8) | 50% 3 | 14.1 | 50% 3 | 51.89 | [63] |
|
L. donovani (MHOM/ET/1967/L82) |
94% (72h) | 25 | 62% (72h) | 25 | [106] |
|
L. mexicana (MHOM/VE/80/NR) |
50% 3 | 9.85 | 50% 3 | 42.08 | [63] |
|
L. mexicana (MHOM/ES/2002/LLM-1162) |
50% 3 | 12. 44 | 50% 3 | 40.67 | [63] |
|
L. mexicana (MHOM/BZ/82/BEL21) |
50% 3 | 10.25 | 50% 3 | 39.54 | [63] |
|
L. brazilensis (MHOM/BR/75/M2903) |
50% 3 | 14. 6 | 50% 3 | 36 | [63] |
|
L. braziliensis (MCAN/BR/1998/619) |
95% (72h) | 25 | 13% (72h) | 25 | [106] |
INHIBITON – Inhibition in relation to control. The number in brackets corresponds to the time when the inhibition was assayed.
Conc. – Concnetration of the inhibitor in µM.
1
The drugs were screened from 15 to 500 µM and the growth followed from 24 to 96 h. The inhibition observed was only marginal.
2
The drugs were screened at 12.5 and 25 µM and the growth compared to the control group after 72 h of incubation, no inhibition was observed.
3
The methodology described in ref [82] was elusive in relation to the time of incubation where the IC50 was calculated.
4
Strains isolated from HIV/Leishmania co-infected patient.